How our Saffron Safr'Inside™ works

Saffron increases the availability of serotonin in the brain, a key hormone involved in regulating anxiety, mood stability, processing fear, and the sleep-wake cycle. Saffron works in a similar way to antidepressant medications by slowing down the degradation of serotonin. ¹

Safranal, the active compound in saffron, interacts with the GABA system. GABA (gamma-aminobutyric acid) is the brain’s main inhibitory neurotransmitter and reduces hyperarousal of the nervous system, promotes relaxation, decreases feelings of tension and restlessness, and supports sleep quality.²

Saffron contains carotenoid compounds (crocin derivatives) and polyphenols which have antioxidant and anti-inflammatory properties, which may help regulate the biological stress response.³

The HPA axis controls the body’s response to stress, and activation of the HPA axis can contribute to raised cortisol, disrupted sleep and feelings of being on edge. Saffron helps modulate the stress response and supports a balanced cortisol response.⁴

Saffron’s crocin compounds impact dopamine, an important hormone for feelings of motivation, reward, and emotional wellbeing. Glutamate is the brain’s main excitatory neurotransmitter, and excess glutamate can lead to anxiety. Crocin works on the glutamatergic pathways, helping provide neuroprotective support. ⁵

Saffron supports sleep quality, duration, and reduces the number of awakenings, reducing stress signaling and improving mood regulation.⁶

Lemon balm may also support sleep quality and satisfaction by reducing nervous system excitability, promoting relaxation before sleep, and supporting a healthy sleep-wake cycle.⁷

Chronic gut inflammation increases intestinal permeability which allows bacterial products to enter into the blood. This activates inflammation that can influence brain function through the gut-brain axis. Crocin, crocetin and other saffron polyphenols have been shown to reduce inflammation and reduce oxidative stress. Studies suggest saffron may help preserve gut barrier integrity, probiotic colonies and reduce inflammatory signalling between the gut and brain.⁸

Polyphenols in Lemon balm may also help regulate inflammatory pathways, support intestinal barrier integrity, and healthy gut-brain communication.⁹